Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA. Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA. Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA. Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. Department of Statistics, University of Oxford, Oxford, UK. Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK. MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK. Department of Twin Research and Genetic Epidemiology, King's College London, London, UK. Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK. School of Computer Science, McGill University, Montreal, Quebec, Canada. McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada. Human Genetics Center, The University of Texas Graduate School of Biomedical Sciences at Houston, The University of Texas Health Science Center at Houston, Houston, Texas, USA. Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA. National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA. Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA. Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA. Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, University of Basel, Basel, Switzerland. Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany. Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Germany. DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany. The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, Illinois, USA. Department of Statistics, Seoul National University, Seoul, Republic of Korea. Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA. Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea. The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA. Departments of Computational Medicine & Bioinformatics and Human Genetics, University of Michigan, Ann Arbor, Michigan, USA. Department of Clinical Sciences, Lund University Diabetes Centre, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden. Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, Colorado, USA. Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore. Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore. The Eye Academic Clinical Programme, Duke-NUS Graduate Medical School, Singapore, Singapore. Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Republic of Korea. Department of Human Genetics, McGill University, Montreal, Quebec, Canada. Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada. Department of Epidemiology and Biostatistics, Imperial College London, London, UK. Department of Cardiology, Ealing Hospital NHS Trust, Southall, Middlesex, UK. Departments of Medicine and Genetics, Albert Einstein College of Medicine, New York, USA. Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania-Perelman School of Medicine, Philadelphia, Pennsylvania, USA. Department of Genetics, University of Pennsylvania-Perelman School of Medicine, Philadelphia, Pennsylvania, USA. Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA. Research, South Texas Veterans Health Care System, San Antonio, Texas, USA. Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland. Kuopio University Hospital, Kuopio, Finland. Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. Centre for Research in Epidemiology and Population Health, Inserm U1018, Villejuif, France. German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany. Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden. Centre for Chronic Disease Control, New Delhi, India. The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, USA. National Heart and Lung Institute, Cardiovascular Sciences, Hammersmith Campus, Imperial College London, London, UK. Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington, USA. Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA. Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA. Department of Psychiatry, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, USA. Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, Republic of Korea. Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Center for Non-Communicable Diseases, Karachi, Pakistan. Cardiovascular Division, Baylor College of Medicine, Houston, Texas, USA. Department of Pediatrics, University of Texas Health Science Center, San Antonio, Texas, USA. Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore. Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain. CIBER Epidemiología y Salud Pública (CIBERESP), Spain. Unit of Preventive Medicine and Public Health, School of Medicine, University of Murcia, Spain. Cancer Research and Prevention Institute (ISPO), Florence, Italy. Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA. South Texas Diabetes and Obesity Institute, Regional Academic Health Center, University of Texas Health Science Center at San Antonio/University of Texas Rio Grande Valley, Brownsville, Texas, USA. Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USA. Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, Mississippi, USA. Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore. Division of Human Genetics, Genome Institute of Singapore, A*STAR, Singapore, Singapore. CNRS-UMR8199, Lille University, Lille Pasteur Institute, Lille, France. Institute of Health Sciences, University of Oulu, Oulu, Finland. Translational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. Jackson Heart Study, University of Mississippi Medical Center, Jackson, Mississippi, USA. College of Public Services, Jackson State University, Jackson, Mississippi, USA. KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway. Department of Pediatrics, Haukeland University Hospital, Bergen, Norway. NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, UK. Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden. Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany. German Center for Diabetes Research (DZD), München-Neuherberg, Germany. Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark. Department of Clinical Biochemistry, Vejle Hospital, Vejle, Denmark. Department of Internal Medicine and Endocrinology, Vejle Hospital, Vejle, Denmark. Department of Health, National Institute for Health and Welfare, Helsinki, Finland. Abdominal Center: Endocrinology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland. Minerva Foundation Institute for Medical Research, Helsinki, Finland. Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland. Division of Cardiovascular and Diabetes Medicine, Medical Research Institute, Ninewells Hospital and Medical School, Dundee, UK. Estonian Genome Center, University of Tartu, Tartu, Estonia. Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA. Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, USA. Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK. Folkhälsan Research Centre, Helsinki, Finland. Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland. Steno Diabetes Center, Gentofte, Denmark. Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup, Denmark. Department of Public Health, Institute of Health Sciences, University of Copenhagen, Copenhagen, Denmark. Faculty of Medicine, Aalborg University, Aalborg, Denmark. Department of Primary Health Care, Vaasa Central Hospital, Vaasa, Finland. Diabetes Center, Vaasa Health Care Center, Vaasa, Finland. Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany. Department of Public Health, Section of General Practice, Aarhus University, Aarhus, Denmark. Department of Clinical Experimental Research, Rigshospitalet, Glostrup, Denmark. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Department of Clinical Sciences, Hypertension and Cardiovascular Disease, Lund University, Malmö, Sweden. Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK. Department of Clinical Sciences, Diabetes and Cardiovascular Disease, Genetic Epidemiology, Lund University, Malmö, Sweden. Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, USA. Division of Endocrinology and Diabetology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany. Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden. High Throughput Genomics, Oxford Genomics Centre, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK. Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. Center of Life and Food Sciences Weihenstephan, Technische Universität München, Freising-Weihenstephan, Germany. William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia. Department of Clinical Sciences, Medicine, Lund University, Malmö, Sweden. Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. Department of Social Services and Health Care, Jakobstad, Finland. Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK. Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Medical Research Institute, Ninewells Hospital and Medical School, Dundee, UK. Foundation for Research in Health, Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland. Center for Vascular Prevention, Danube University Krems, Krems, Austria. Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia. Dasman Diabetes Institute, Dasman, Kuwait. National Institute for Health and Welfare, Helsinki, Finland. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. Department of Physiology & Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. Diabetes and Obesity Research Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden. Cedars-Sinai Diabetes and Obesity Research Institute, Los Angeles, California, USA. Functional Genomics Unit, CSIR-Institute of Genomics & Integrative Biology (CSIR-IGIB), New Delhi, India. Department of Biomedical Science, Hallym University, Chuncheon, Republic of Korea. CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Telangana, India. Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China. Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China. MRC-PHE Centre for Environment and Health, Imperial College London, London, UK. The Biostatistics Center, The George Washington University, Rockville, Maryland, USA. Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, and Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA. Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India. Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, UK. Life Sciences Institute, National University of Singapore, Singapore, Singapore. Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore. Endocrinology and Metabolism Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. The Medical School, Institute of Cellular Medicine, Newcastle University, Newcastle, UK. Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden. Hannover Unified Biobank, Hannover Medical School, Hanover, Germany. Department of Human Genetics, Hannover Medical School, Hanover, Germany. Department of Medical Sciences, Uppsala University, Uppsala, Sweden. Data Sciences and Data Engineering, Broad Institute, Cambridge, Massachusetts, USA. Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland. Imperial College Healthcare NHS Trust, Imperial College London, London, UK. Clinical Research Centre, Centre for Molecular Medicine, Ninewells Hospital and Medical School, Dundee, UK. The Usher Institute to the Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. University of Exeter Medical School, University of Exeter, Exeter, UK. Department of Natural Science, University of Haifa, Haifa, Israel. Institute of Human Genetics, Technische Universität München, Munich, Germany. Departments of Medicine and Human Genetics, The University of Chicago, Chicago, Illinois, USA. Cardiovascular & Metabolic Disorders Program, Duke-NUS Medical School Singapore, Singapore, Singapore. Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK. Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA. Department of Laboratory Medicine & Institute for Human Genetics, University of California, San Francisco, San Francisco, California, USA. Blood Systems Research Institute, San Francisco, California, USA. General Medicine Division, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA. Division of Endocrinology and Metabolism, Department of Medicine, McGill University, Montreal, Quebec, Canada. Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA. Department of Biostatistics, University of Liverpool, Liverpool, UK. Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA. Diabetes Research Center (Diabetes Unit), Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.